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Targeted Allele Detail
Symbol: Scnn1btm1Wsh
Name: sodium channel, nonvoltage-gated 1 beta; targeted mutation 1, Michael J Welsh
MGI ID: MGI:2179819
Synonyms: betaENaC -
Gene: Scnn1b  Location: Chr7:121865038-121918514 bp, + strand  Genetic Position: Chr7, 65.07 cM
Germline Transmission:  Earliest citation of germline transmission: J:53058
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing the first exon and part of the first intron. RT-PCR analysis on lung and kidney mRNA derived from homozygous mice demonstrated that no detectable transcript is expressed from this allele. (J:53058)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scnn1b Mutation:  30 strains or lines available
Original:  J:53058 McDonald FJ, et al., Disruption of the beta subunit of the epithelial Na+ channel in mice: hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1727-31
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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