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Scnn1btm1Wsh
Targeted Allele Detail
Nomenclature
Symbol: Scnn1btm1Wsh
Name: sodium channel, nonvoltage-gated 1 beta; targeted mutation 1, Michael J Welsh
MGI ID: MGI:2179819
Synonyms: betaENaC -
Gene: Scnn1b  Location: Chr7:121865038-121918514 bp, + strand  Genetic Position: Chr7, 65.07 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53058
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing the first exon and part of the first intron. RT-PCR analysis on lung and kidney mRNA derived from homozygous mice demonstrated that no detectable transcript is expressed from this allele. (J:53058)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scnn1b Mutation:  30 strains or lines available
References
Original:  J:53058 McDonald FJ, et al., Disruption of the beta subunit of the epithelial Na+ channel in mice: hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1727-31
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/18/2018
MGI 6.12
The Jackson Laboratory