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Targeted Allele Detail
Symbol: Synj1tm1Pdc
Name: synaptojanin 1; targeted mutation 1, Pietro De Camilli
MGI ID: MGI:2179801
Gene: Synj1  Location: Chr16:90732980-90808196 bp, - strand  Genetic Position: Chr16, 52.18 cM, cytoband C3-C4
Germline Transmission:  Earliest citation of germline transmission: J:58087
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing part of exon 1 and part of intron 1. Western blot analysis on brain tissue of homozygous mice demonstrated that no detectable protein was expressed from this allele. (J:58087)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Synj1 Mutation:  42 strains or lines available
Original:  J:58087 Cremona O, et al., Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cell. 1999 Oct 15;99(2):179-88
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory