Snta1^tm1Stk
Targeted Allele Detail

Summary

• Symbol: Snta1^tm1Stk
• Name: syntrophin, acidic 1; targeted mutation 1, Shin'ichi Takeda
• MGI ID: MGI:2179768
• Gene: Snta1 Location: Chr2:154218234-154250004 bp, - strand Genetic Position: Chr2, 76.52 cM
• Alliance: Snta1^tm1Stk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52275
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 2. Northern blot analysis on mRNA derived from skeletal muscle of homozygous mice confirmed that no transcript was expressed from this allele. Western blot analysis on skeletal muscle lysates derived from homozygous mice demonstrated that no detectable encoded protein was present. (J:52275)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snta1 Mutation: 34 strains or lines available

References

• Original: J:52275 Kameya S, et al., alpha1-syntrophin gene disruption results in the absence of neuronal-type nitric-oxide synthase at the sarcolemma but does not induce muscle degeneration. J Biol Chem. 1999 Jan 22;274(4):2193-200
• All: 2 reference(s)