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Tbr1tm1Jlr
Targeted Allele Detail
Nomenclature
Symbol: Tbr1tm1Jlr
Name: T-box brain transcription factor 1; targeted mutation 1, John L Rubenstein
MGI ID: MGI:2179766
Gene: Tbr1  Location: Chr2:61802930-61814114 bp, + strand  Genetic Position: Chr2, 35.56 cM
Premature overgrowth and superabundance of subcortical axons in the brainstem of Tbr1tm1Jlr/Tbr1tm1Jlr Tg(Mbp-MAPT/EGFP)#Eja/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51888
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3, which encode a putative DNA-binding domain, were replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant animals were identified by Southern blot and PCR genotype analysis. (J:51888)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tbr1 Mutation:  21 strains or lines available
References
Original:  J:51888 Bulfone A, et al., An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. Neuron. 1998 Dec;21(6):1273-82
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory