About   Help   FAQ
Targeted Allele Detail
Symbol: Scn5atm1Agrc
Name: sodium channel, voltage-gated, type V, alpha; targeted mutation 1, Andrew A Grace
MGI ID: MGI:2179753
Synonyms: Scn5a-
Gene: Scn5a  Location: Chr9:119483408-119579016 bp, - strand  Genetic Position: Chr9, 71.33 cM
Morphology of E10.5 control and Scn5atm1Agrc/Scn5atm1Agrc hearts

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:76331
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was replaced with a splice acceptor (SA)-Gfp-PGK-neo cassette via homologous recombination. RT-PCR analysis verified the lack of gene expression in homozygous mutant animals. (J:76331)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn5a Mutation:  61 strains or lines available
Original:  J:76331 Papadatos GA, et al., Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6210-5
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.16
The Jackson Laboratory