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Sv2btm1Sud
Targeted Allele Detail
Summary
Symbol: Sv2btm1Sud
Name: synaptic vesicle glycoprotein 2b; targeted mutation 1, Thomas C Sudhof
MGI ID: MGI:2179737
Synonyms: SV2B-
Gene: Sv2b  Location: Chr7:74764642-74959010 bp, - strand  Genetic Position: Chr7, 43.62 cM, cytoband D1
Alliance: Sv2btm1Sud page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:59180
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced the first coding exon and flanking sequences. Western blot analysis on brain lysates derived from homozygous mice confirmed that no detectable encoded protein was made. (J:59180)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sv2b Mutation:  58 strains or lines available
References
Original:  J:59180 Janz R, et al., SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release. Neuron. 1999 Dec;24(4):1003-16
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory