Sv2a^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Sv2a^tm1Sud
• Name: synaptic vesicle glycoprotein 2a; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:2179736
• Synonyms: SV2A-
• Gene: Sv2a Location: Chr3:96088543-96102499 bp, + strand Genetic Position: Chr3, 41.65 cM, cytoband F2
• Alliance: Sv2a^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59180
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exons 2-9. Western blot analysis on brain lysates derived from homozygous mice demonstrated that no detectable protein was expressed from this allele. (J:59180)

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sv2a Mutation: 36 strains or lines available

References

• Original: J:59180 Janz R, et al., SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release. Neuron. 1999 Dec;24(4):1003-16
• All: 4 reference(s)