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Targeted Allele Detail
Symbol: Sv2atm1Sud
Name: synaptic vesicle glycoprotein 2 a; targeted mutation 1, Thomas C Sudhof
MGI ID: MGI:2179736
Synonyms: SV2A-
Gene: Sv2a  Location: Chr3:96181151-96195521 bp, + strand  Genetic Position: Chr3, 41.65 cM, cytoband F2
Germline Transmission:  Earliest citation of germline transmission: J:59180
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exons 2-9. Western blot analysis on brain lysates derived from homozygous mice demonstrated that no detectable protein was expressed from this allele. (J:59180)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sv2a Mutation:  18 strains or lines available
Original:  J:59180 Janz R, et al., SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release. Neuron. 1999 Dec;24(4):1003-16
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
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