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Cacna1etm1Ttan
Targeted Allele Detail
Nomenclature
Symbol: Cacna1etm1Ttan
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit; targeted mutation 1, Tsutomu Tanabe
MGI ID: MGI:2179732
Synonyms: alpha(1E)-, alpha1E-, Cav2.3-
Gene: Cacna1e  Location: Chr1:154390731-154884501 bp, - strand  Genetic Position: Chr1, 66.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62285
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsExon 1 of this gene was disrupted by insertion of a lacZneo-derived cassette via homologous recombination. RT-PCR and Northern blot analysis of brain RNA and Western blot analysis of brain membrane proteins from homozygous mutant animals verified the absence of gene expression. (J:62285)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cacna1e Mutation:  55 strains or lines available
References
Original:  J:62285 Saegusa H, et al., Altered pain responses in mice lacking alpha 1E subunit of the voltage-dependent Ca2+ channel. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6132-7
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory