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Rph3atm1Sud
Targeted Allele Detail
Nomenclature
Symbol: Rph3atm1Sud
Name: rabphilin 3A; targeted mutation 1, Thomas C Sudhof
MGI ID: MGI:2179730
Synonyms: rabphilin KO
Gene: Rph3a  Location: Chr5:120940499-121010092 bp, - strand  Genetic Position: Chr5, 61.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:56293
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced two exons encoding residues 74-146 of the encoded protein. Western blot analysis on brain tissues of homozygous mice confirmed that no encoded protein was detected. (J:56293)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rph3a Mutation:  16 strains or lines available
References
Original:  J:56293 Schluter OM, et al., Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release. J Neurosci. 1999 Jul 15;19(14):5834-46
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory