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Targeted Allele Detail
Symbol: Nfkb2tm1Sbn
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; targeted mutation 1, Ulrich Siebenlist
MGI ID: MGI:2179705
Synonyms: NF-kappaB/p52 null, Nfkb2-, p52/p100-
Gene: Nfkb2  Location: Chr19:46304320-46312090 bp, + strand  Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
Germline Transmission:  Earliest citation of germline transmission: J:45437
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced sequences encoding the dimerization/DNA binding domain, the nuclear translocation sequence and the first seven ankyrin domains. Western blot analysis on lysates derived from spleen of homozygous mice confirmed that no detectable isoform of the encoded protein was present. (J:45437)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfkb2 Mutation:  38 strains or lines available
Original:  J:45437 Franzoso G, et al., Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture. J Exp Med. 1998 Jan 19;187(2):147-59
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory