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Lefty2tm1Hmd
Targeted Allele Detail
Nomenclature
Symbol: Lefty2tm1Hmd
Name: left-right determination factor 2; targeted mutation 1, Hiroshi Hamada
MGI ID: MGI:2179551
Synonyms: lefty2-
Gene: Lefty2  Location: Chr1:180893108-180899103 bp, + strand  Genetic Position: Chr1, 84.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57907
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAll 4 exons of this gene were replaced with a neomycin resistance cassette via homologous recombination. Homozygous mutant embryos at E8.5 and E11.5 were identified by Southern blot analysis. (J:57907)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lefty2 Mutation:  12 strains or lines available
References
Original:  J:57907 Meno C, et al., Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol Cell. 1999 Sep;4(3):287-98
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory