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Lefty1tm1Hmd
Targeted Allele Detail
Nomenclature
Symbol: Lefty1tm1Hmd
Name: left right determination factor 1; targeted mutation 1, Hiroshi Hamada
MGI ID: MGI:2179534
Synonyms: lefty-1-, Lefty1null
Gene: Lefty1  Location: Chr1:180935022-180938400 bp, + strand  Genetic Position: Chr1, 84.46 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49052
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAll 4 exons of this gene were replaced with a neo cassette via homologous recombination. Homozygous mutant animals were identified via Southern blot analysis. (J:49052)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lefty1 Mutation:  4 strains or lines available
References
Original:  J:49052 Meno C, et al., lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell. 1998 Aug 7;94(3):287-97
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory