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Targeted Allele Detail
Symbol: Smad2tm1Rak
Name: SMAD family member 2; targeted mutation 1, Raju Kucherlapati
MGI ID: MGI:2179521
Synonyms: Smad2dex2
Gene: Smad2  Location: Chr18:76241580-76310963 bp, + strand  Genetic Position: Chr18, 51.42 cM
Germline Transmission:  Earliest citation of germline transmission: J:73507
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 and a 1.5 kb region preceding exon 2 were replaced with a PGK-neo cassette via homologous recombination resulting in deletion of the start codon. Western blot of protein extracts from homozygous mutant animals confirmed the absence of protein product. (J:73507)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad2 Mutation:  16 strains or lines available
Original:  J:73507 Heyer J, et al., Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12595-600
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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