Or10a4^tm1Mom
Targeted Allele Detail

Summary

• Symbol: Or10a4^tm1Mom
• Name: olfactory receptor family 10 subfamily A member 4; targeted mutation 1, Peter Mombaerts
• MGI ID: MGI:2179510
• Synonyms: OR-lacZ, P2-IRES-taulacZ, P2-IRES-tau::lacZ, P2*-LacZ, P2^TL
• Gene: Or10a4 Location: Chr7:106696674-106697621 bp, + strand Genetic Position: Chr7, 56.1 cM, cytoband F2
• Alliance: Or10a4^tm1Mom page

Impaired glomerular formation in Ttc8^tm1Reed/Ttc8^tm1Reed Or10a4^tm1Mom/Or10a4⁺ neonatal pups

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36595
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: Insertion of an IRES-tau-lacZ-loxP-tk-neo-loxP expression cassette placed the inserted sequences under control of the endogenous regulatory sequences. Transient expression of Cre recombinase in C57BL/6 blastocysts excised the thymidine kinase and neomycin sequences. This allele expresses a bicistronic mRNA encoding the receptor and a bovine tau-beta-galactosidase fusion protein. (J:36595, J:99181)

Expression

In Mice Carrying this Mutation:

38 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Or10a4 Mutation: 22 strains or lines available

References

• Original: J:36595 Mombaerts P, et al., Visualizing an olfactory sensory map. Cell. 1996 Nov 15;87(4):675-86
• All: 41 reference(s)