About   Help   FAQ
Targeted Allele Detail
Symbol: Dffatm1Mxu
Name: DNA fragmentation factor, alpha subunit; targeted mutation 1, Ming Xu
MGI ID: MGI:2179456
Synonyms: DFF45 -
Gene: Dffa  Location: Chr4:149104146-149120647 bp, + strand  Genetic Position: Chr4, 78.87 cM
Germline Transmission:  Earliest citation of germline transmission: J:50707
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing the first three exons of the gene. Western blot analysis on extracts of various tissues derived from homozygous mice confirmed that no protein was expressed from this allele. (J:50707)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dffa Mutation:  6 strains or lines available
Original:  J:50707 Zhang J, et al., Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12480-5
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.06
The Jackson Laboratory