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Targeted Allele Detail
Symbol: Tnfsf9tm1Thw
Name: tumor necrosis factor (ligand) superfamily, member 9; targeted mutation 1, Tania H Watts
MGI ID: MGI:2179297
Synonyms: 4-1BBL-, 41BBL KO, CD137L-
Gene: Tnfsf9  Location: Chr17:57105385-57107757 bp, + strand  Genetic Position: Chr17, 29.67 cM
Germline Transmission:  Earliest citation of germline transmission: J:76373
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a PGK-neo cassette at nucleotide 52 via homologous recombination. Activated lymph node cells from homozygous mutant animals did not contain protein product as assayed by flow cytometry. (J:76373)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfsf9 Mutation:  10 strains or lines available
Original:  J:76373 DeBenedette MA, et al., Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus. J Immunol. 1999 Nov 1;163(9):4833-41
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory