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Aggr1NZB/BlNJ
QTL Variant Detail
Summary
QTL variant: Aggr1NZB/BlNJ
Name: aggression 1; NZB/BlNJ
MGI ID: MGI:2179250
QTL: Aggr1  Location: Chr10:119506908-125575232 bp  Genetic Position: Chr10, Syntenic
Variant
origin
Strain of Specimen:  NZB/BlNJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased aggressive behavior in male animals compared to A/J. (J:74459)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:74459

Genome scan at an average marker resolution of 20 cM was performed on (NZB/BlNJ x A/J)F1 x A/J backcross animals to identify loci associated with aggressive behavior. NZB/BlNJ males exhibit extremely aggressive behavior whereas A/J males are extremely unaggressive.

Loci significantly associated with aggression, Aggr1 and Aggr2, mapped to 67.5 cM - 70 cM on mouse Chromosome 10 (LOD=6.3, between markers D10Mit267 and D10Mit103) and 14.5 cM - 17.2 cM mouse Chromosome X (LOD=5.0, between markers DXMit105 and DXMit159), respectively.

NZB/BlNJ-derived alleles confer aggressive behavior in a dominant and fully penetrant manner at both loci. Aggr1 and Aggr2 do not appear epistatic but exhibit additive interaction. Possible candidate genes for Aggr1 include Dgka, Kif5a, and Olfr9. Possible candidate genes for Aggr2 include Gria3 and Hprt.

References
Original:  J:74459 Brodkin ES, et al., Identification of quantitative trait Loci that affect aggressive behavior in mice. J Neurosci. 2002 Feb 1;22(3):1165-70
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory