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Targeted Allele Detail
Symbol: Tff3tm1Dkpy
Name: trefoil factor 3, intestinal; targeted mutation 1, Daniel K Podolsky
MGI ID: MGI:2179219
Synonyms: Itf-
Gene: Tff3  Location: Chr17:31125306-31129611 bp, - strand  Genetic Position: Chr17, 15.8 cM
Germline Transmission:  Earliest citation of germline transmission: J:35882
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 of this gene was replaced with a neo cassette via homologous recombination resulting in the deletion of the trefoil domain. Absence of gene expression in the gastrointestinal tract of homozygous mutant animals was confirmed by Northern blot analysis and immunohistochemistry. (J:35882)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tff3 Mutation:  7 strains or lines available
Original:  J:35882 Mashimo H, et al., Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor [see comments]. Science. 1996 Oct 11;274(5285):262-5
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory