About   Help   FAQ
Slc6a6tm1Dhau
Targeted Allele Detail
Summary
Symbol: Slc6a6tm1Dhau
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6; targeted mutation 1, Dieter Haussinger
MGI ID: MGI:2179132
Synonyms: taut-
Gene: Slc6a6  Location: Chr6:91661031-91736044 bp, + strand  Genetic Position: Chr6, 40.73 cM
Alliance: Slc6a6tm1Dhau page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74276
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 of this gene was replaced with a neomycin resistance gene via homologous recombination, resulting in a truncated protein deleted for transmembrane domains 1-2 as well as a large portion of the extracellular region. Transcripts including exon 1 were not expressed in kidney and liver of homozygous mutant animals as assayed by Northern blot. (J:74276)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a6 Mutation:  319 strains or lines available
References
Original:  J:74276 Heller-Stilb B, et al., Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice. FASEB J. 2002 Feb;16(2):231-3
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory