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Slc6a6tm1Dhau
Targeted Allele Detail
Nomenclature
Symbol: Slc6a6tm1Dhau
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6; targeted mutation 1, Dieter Haussinger
MGI ID: MGI:2179132
Synonyms: taut-
Gene: Slc6a6  Location: Chr6:91684053-91759066 bp, + strand  Genetic Position: Chr6, 40.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74276
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 of this gene was replaced with a neomycin resistance gene via homologous recombination, resulting in a truncated protein deleted for transmembrane domains 1-2 as well as a large portion of the extracellular region. Transcripts including exon 1 were not expressed in kidney and liver of homozygous mutant animals as assayed by Northern blot. (J:74276)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a6 Mutation:  304 strains or lines available
References
Original:  J:74276 Heller-Stilb B, et al., Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice. FASEB J. 2002 Feb;16(2):231-3
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory