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Ppm1dtm1Lad
Targeted Allele Detail
Nomenclature
Symbol: Ppm1dtm1Lad
Name: protein phosphatase 1D magnesium-dependent, delta isoform; targeted mutation 1, Lawrence A Donehower
MGI ID: MGI:2179128
Synonyms: Wip1-, WIP1-
Gene: Ppm1d  Location: Chr11:85311244-85347066 bp, + strand  Genetic Position: Chr11, 51.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74284
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 and 5 were replaced with a PGK-puro cassette via homologous recombination resulting in protein truncation. Northern blot analysis of tissues from homozygous mutant animals did not detect gene transcript although a transcript with deleted exons 4 and 5, presumed to be unstable, was detected by RT-PCR. Western blot of irradiated testes from homozygous mutants did not detect protein product. (J:74284)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppm1d Mutation:  3 strains or lines available
References
Original:  J:74284 Choi J, et al., Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control. Mol Cell Biol. 2002 Feb;22(4):1094-105
All:  18 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory