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Nox3het-3J
Chemically induced Allele Detail
Nomenclature
Symbol: Nox3het-3J
Name: NADPH oxidase 3; head tilt 3 Jackson
MGI ID: MGI:2179106
Synonyms: vst
Gene: Nox3  Location: Chr17:3685515-3746536 bp, - strand  Genetic Position: Chr17, 2.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89010
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Chemically induced (other) (Null/knockout)
Mutation:    Single point mutation
 
Mutation detailsA G to A transition at the -1 position of the spice acceptor site at the intron 1 - exon 2 junction is predicted to result in the abolition of this acceptor site. As a result, PCR suggests two splice variants in the homozygous mutant: one using a cryptic acceptor site in intron 1 and then the canonical donor site of exon 2 (resulting in novel amino-acids and a premature stop codon) and one skipping exon 2 (with the coding region remaining in-frame). No complementation was seen among offspring in crosses between heterozygotes of this allele and homozygotes of head tilt or head tilt 2 Jackson. (J:89010, J:169054)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nox3 Mutation:  26 strains or lines available
References
Original:  J:76316 Monroe RJ, et al., A new allele at the head-tilt (het) locus. MGI Direct Data Submission. 2002;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory