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Tff2tm1Tcw
Targeted Allele Detail
Nomenclature
Symbol: Tff2tm1Tcw
Name: trefoil factor 2 (spasmolytic protein 1); targeted mutation 1, Timothy C Wang
MGI ID: MGI:2179101
Synonyms: TFF2-
Gene: Tff2  Location: Chr17:31141049-31144282 bp, - strand  Genetic Position: Chr17, 15.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74338
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-4 of this gene were replaced with a neomycin cassette via homologous recombination. Northern and Western blot analysis confirmed the absence of gene expression in homozygous mutant animals. (J:74338)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tff2 Mutation:  8 strains or lines available
References
Original:  J:74338 Farrell JJ, et al., TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury. J Clin Invest. 2002 Jan;109(2):193-204
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory