Tff2^tm1Tcw
Targeted Allele Detail

Summary

• Symbol: Tff2^tm1Tcw
• Name: trefoil factor 2 (spasmolytic protein 1); targeted mutation 1, Timothy C Wang
• MGI ID: MGI:2179101
• Synonyms: TFF2^-
• Gene: Tff2 Location: Chr17:31360036-31363256 bp, - strand Genetic Position: Chr17, 15.8 cM
• Alliance: Tff2^tm1Tcw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74338
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-4 of this gene were replaced with a neomycin cassette via homologous recombination. Northern and Western blot analysis confirmed the absence of gene expression in homozygous mutant animals. (J:74338)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tff2 Mutation: 12 strains or lines available

References

• Original: J:74338 Farrell JJ, et al., TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury. J Clin Invest. 2002 Jan;109(2):193-204
• All: 11 reference(s)