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Grin2btm2Mim
Targeted Allele Detail
Nomenclature
Symbol: Grin2btm2Mim
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2); targeted mutation 2, Masayoshi Mishina
MGI ID: MGI:2179059
Synonyms: GluRepsilon2dC
Gene: Grin2b  Location: Chr6:135713233-136173511 bp, - strand  Genetic Position: Chr6, 66.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76019
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA termination codon and a neomycin selection cassette were replaced 0.9 kb of the sequences following codon 997. RNAase protection assays on RNA derived from brain of homozyous mice demonstrated that normal levels of a mutant transcript are produced from this allele. Western blot analysis on whole brain lysates confirmed that a truncated protein is expressed from this allele in homozygous mice. (J:76019)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grin2b Mutation:  45 strains or lines available
References
Original:  J:76019 Mori H, et al., Role of the carboxy-terminal region of the GluR epsilon2 subunit in synaptic localization of the NMDA receptor channel. Neuron. 1998 Sep;21(3):571-80
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory