About   Help   FAQ
Oprm1tm1Jep
Targeted Allele Detail
Nomenclature
Symbol: Oprm1tm1Jep
Name: opioid receptor, mu 1; targeted mutation 1, John E Pintar
MGI ID: MGI:2179052
Synonyms: MOP-R-, MOR-1 -, MOR-1 KO
Gene: Oprm1  Location: Chr10:6758506-7038198 bp, + strand  Genetic Position: Chr10, 1.85 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52952
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 and flanking intronic sequences were replaced with a neomycin resistance cassette. Binding assays on brain tissues of homozygous mice confirmed that no functional protein was expressed from this allele. (J:52952)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oprm1 Mutation:  24 strains or lines available
References
Original:  J:52952 Schuller AG, et al., Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1. Nat Neurosci. 1999 Feb;2(2):151-6
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/15/2017
MGI 6.10
The Jackson Laboratory