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Tg(GFAP-cre)25Mes
Transgene Detail
Summary
Symbol: Tg(GFAP-cre)25Mes
Name: transgene insertion 25, Albee Messing
MGI ID: MGI:2179048
Synonyms: Gfa2-Cre, GFAP-Cre, GFAP-Cre-m, hGFAPcre, hGFAP-cre, hGFAP::Cre, Tg95.2, TgN25Mes, TgN(GFAPcre)25Mes
Transgene: Tg(GFAP-cre)25Mes  Location: unknown  
Alliance: Tg(GFAP-cre)25Mes page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(GFAP-cre)25Mes expression driven by 1 gene
 
Mutation detailsThis transgene expresses Cre recombinase under the control of a human glial fibrillary acidic protein (GFAP) promoter. Cre-mediated recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. Expression activity is also present in periportal cells of the liver. Developmental onset of transgene expression occurs in the dorsal and medial regions of the telencephalon by embryonic day 13.5. In adult cerebellum, only astrocytes are immunoreactive for GFAP or Cre recombinase. (J:72509)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: GFAP (human)
Summary of all recombinase alleles driven by GFAP.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
Tumor Data
List all tumor models in MMHCdb carrying Tg(GFAP-cre)25Mes
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Mice that are homozygous for the transgene are not viable.
References
Original:  J:72509 Zhuo L, et al., hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis. 2001 Oct;31(2):85-94
All:  391 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory