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Sycp3tm1Hoog
Targeted Allele Detail
Nomenclature
Symbol: Sycp3tm1Hoog
Name: synaptonemal complex protein 3; targeted mutation 1, Christer Hoog
MGI ID: MGI:2179041
Synonyms: SCP3-
Gene: Sycp3  Location: Chr10:88459569-88473236 bp, + strand  Genetic Position: Chr10, 43.94 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60153
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-3 were replaced with a neomycin cassette via homologous recombination. Gene transcripts and protein were absent in testes of adult homozygous mutant animals as assayed by Northern and Western blot, respectively. (J:60153)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sycp3 Mutation:  12 strains or lines available
References
Original:  J:60153 Yuan L, et al., The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility. Mol Cell. 2000 Jan;5(1):73-83
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory