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Dmc1tm1Tkm
Targeted Allele Detail
Nomenclature
Symbol: Dmc1tm1Tkm
Name: DNA meiotic recombinase 1; targeted mutation 1, Takashi Morita
MGI ID: MGI:2179026
Synonyms: Dmc1-
Gene: Dmc1  Location: Chr15:79561500-79605084 bp, - strand  Genetic Position: Chr15, 37.79 cM, cytoband E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47307
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 of this gene was replaced with a neomycin cassette via homologous recombination. Northern blot analysis of mutant animals detected larger RNA species due to insertion of the neo cassette. Western blot and immunohistochemistry did not detect protein in nuclear extract from testis of homozygous mutant animals. (J:47307)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dmc1 Mutation:  10 strains or lines available
References
Original:  J:47307 Yoshida K, et al., The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis. Mol Cell. 1998 Apr;1(5):707-18
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory