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Targeted Allele Detail
Symbol: Mdktm1Tmu
Name: midkine; targeted mutation 1, Takashi Muramatsu
MGI ID: MGI:2178959
Synonyms: Mdk-, Mk-
Gene: Mdk  Location: Chr2:91929805-91932297 bp, - strand  Genetic Position: Chr2, 50.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:76278
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details220 bp containing part of exon 1, intron 1 and part of exon 2 was replaced with a neomycin selection cassette. Northern blot analysis on total kidney RNA derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on lysates derived from adult kidney confirmed that no detectable protein was expressed from this allele. (J:76278)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mdk Mutation:  45 strains or lines available
Original:  J:76278 Nakamura E, et al., Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour. Genes Cells. 1998 Dec;3(12):811-22
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory