About   Help   FAQ
Ptpn7tm1Bwz
Targeted Allele Detail
Nomenclature
Symbol: Ptpn7tm1Bwz
Name: protein tyrosine phosphatase, non-receptor type 7; targeted mutation 1, Brent W Zanke
MGI ID: MGI:2178956
Synonyms: HePTP-
Gene: Ptpn7  Location: Chr1:135132700-135145317 bp, + strand  Genetic Position: Chr1, 58.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73798
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 of this gene was replaced with a neomycin expression cassette via homologous recombination. Western blot confirmed that expression was absent in tissue from homozygous mutant animals. (J:73798)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptpn7 Mutation:  1 strain or line available
References
Original:  J:73798 Gronda M, et al., Hematopoietic protein tyrosine phosphatase suppresses extracellular stimulus-regulated kinase activation. Mol Cell Biol. 2001 Oct;21(20):6851-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/26/2019
MGI 6.14
The Jackson Laboratory