Ptpn7^tm1Bwz
Targeted Allele Detail

Summary

• Symbol: Ptpn7^tm1Bwz
• Name: protein tyrosine phosphatase, non-receptor type 7; targeted mutation 1, Brent W Zanke
• MGI ID: MGI:2178956
• Synonyms: HePTP-
• Gene: Ptpn7 Location: Chr1:135060438-135073055 bp, + strand Genetic Position: Chr1, 58.24 cM
• Alliance: Ptpn7^tm1Bwz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73798
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 of this gene was replaced with a neomycin expression cassette via homologous recombination. Western blot confirmed that expression was absent in tissue from homozygous mutant animals. (J:73798)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptpn7 Mutation: 23 strains or lines available

References

• Original: J:73798 Gronda M, et al., Hematopoietic protein tyrosine phosphatase suppresses extracellular stimulus-regulated kinase activation. Mol Cell Biol. 2001 Oct;21(20):6851-8
• All: 2 reference(s)