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Targeted Allele Detail
Symbol: Ptpn7tm1Bwz
Name: protein tyrosine phosphatase, non-receptor type 7; targeted mutation 1, Brent W Zanke
MGI ID: MGI:2178956
Synonyms: HePTP-
Gene: Ptpn7  Location: Chr1:135132700-135145317 bp, + strand  Genetic Position: Chr1, 58.24 cM
Germline Transmission:  Earliest citation of germline transmission: J:73798
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 of this gene was replaced with a neomycin expression cassette via homologous recombination. Western blot confirmed that expression was absent in tissue from homozygous mutant animals. (J:73798)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptpn7 Mutation:  1 strain or line available
Original:  J:73798 Gronda M, et al., Hematopoietic protein tyrosine phosphatase suppresses extracellular stimulus-regulated kinase activation. Mol Cell Biol. 2001 Oct;21(20):6851-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory