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Itktm1Ljb
Targeted Allele Detail
Nomenclature
Symbol: Itktm1Ljb
Name: IL2 inducible T cell kinase; targeted mutation 1, Leslie Berg
MGI ID: MGI:2178928
Synonyms: Itk-
Gene: Itk  Location: Chr11:46325150-46389515 bp, - strand  Genetic Position: Chr11, 27.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48231
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe kinase domain of this gene (amino acids 476-543) spanning from the middle of exon 10 to exon 12 was replaced with a PGK-neo cassette via homologous recombination. Protein product was absent in lymph nodes, spleen, and thymus of homozygous mutant animals via Western blot analysis. (J:48231)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itk Mutation:  31 strains or lines available
Notes
J1 and CCE were used in the generation of this targeted mutation.
References
Original:  J:48231 Liu KQ, et al., T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. J Exp Med. 1998 May 18;187(10):1721-7
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory