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Arnt2tm1Yfk
Targeted Allele Detail
Nomenclature
Symbol: Arnt2tm1Yfk
Name: aryl hydrocarbon receptor nuclear translocator 2; targeted mutation 1, Yoshiaki Fujii-Kuriyama
MGI ID: MGI:2178831
Synonyms: Arnt2-
Gene: Arnt2  Location: Chr7:84246278-84410176 bp, - strand  Genetic Position: Chr7, 48.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74118
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsAn in-frame NLS-LacZ cassette was introduced into this gene via homologous recombination, disrupting the HLH domain which is involved in dimerization and DNA binding. Successful homologous recombination was confirmed by Southern blotting. Protein was not present in brain of neonate homozygous mutant animals via immunohistochemistry analysis. (J:74118)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arnt2 Mutation:  22 strains or lines available
References
Original:  J:74118 Hosoya T, et al., Defective development of secretory neurones in the hypothalamus of Arnt2-knockout mice. Genes Cells. 2001 Apr;6(4):361-74
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory