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Targeted Allele Detail
Symbol: Kcnj11tm1Sse
Name: potassium inwardly rectifying channel, subfamily J, member 11; targeted mutation 1, Susumu Seino
MGI ID: MGI:2178821
Synonyms: Kir6.2-, Kir6.2KO, Kir6.2-KO
Gene: Kcnj11  Location: Chr7:45746547-45750376 bp, - strand  Genetic Position: Chr7, 29.66 cM
Germline Transmission:  Earliest citation of germline transmission: J:49755
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsAn exon of this gene was disrupted by the insertion of a neomycin gene via homologous recombination. No transcripts were detected in the tissues of homozygous mutant animals by RT-PCR analysis. Pancreatic beta cells of homozygous mutant animals did not exhibit membrane current activity as determined by whole cell assays. (J:49755)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnj11 Mutation:  27 strains or lines available
Original:  J:49755 Miki T, et al., Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10402-6
All:  76 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
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