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Npr1tm1Gar
Targeted Allele Detail
Nomenclature
Symbol: Npr1tm1Gar
Name: natriuretic peptide receptor 1; targeted mutation 1, David L Garbers
MGI ID: MGI:2178776
Synonyms: GC-A-, GC-A KO
Gene: Npr1  Location: Chr3:90450591-90465866 bp, - strand  Genetic Position: Chr3, 39.23 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:30007
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin resistance cassette into exon 4, which encodes part of the extra-cellular putative ligand-binding domain, disrupted the gene. Stable, wild-type size transcript was not detected in liver or kidney from homozygous mutant mice. (J:30007)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Npr1 Mutation:  26 strains or lines available
References
Original:  J:30007 Lopez MJ, et al., Salt-resistant hypertension in mice lacking the guanylyl cyclase-A receptor for atrial natriuretic peptide. Nature. 1995 Nov 2;378(6552):65-8
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory