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Drd4tm1Dkg
Targeted Allele Detail
Nomenclature
Symbol: Drd4tm1Dkg
Name: dopamine receptor D4; targeted mutation 1, David K Grandy
MGI ID: MGI:2178631
Synonyms: D4-, D4KO, D4R -, Drd4-
Gene: Drd4  Location: Chr7:141292006-141296464 bp, + strand  Genetic Position: Chr7, 86.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43061
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 2. RT-PCR analysis demonstrated that a mutated transcript was produced from this allele that spliced exon 1 to exon 3. This mutation causes a shift in the reading frame that is predicted to result in the production of a truncated protein. (J:43061)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drd4 Mutation:  26 strains or lines available
References
Original:  J:43061 Rubinstein M, et al., Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell. 1997 Sep 19;90(6):991-1001
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory