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Targeted Allele Detail
Symbol: Hellstm1Kmu
Name: helicase, lymphoid specific; targeted mutation 1, Kathrin Muegge
MGI ID: MGI:2178586
Synonyms: Lsh -
Gene: Hells  Location: Chr19:38930990-38970470 bp, + strand  Genetic Position: Chr19, 33.57 cM, cytoband C3-D1
Germline Transmission:  Earliest citation of germline transmission: J:76112
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 6 and 7, containing a helicase domain (ATPase), and a DExH box, were relaced with a PGK-neo cassette. Successful targeting was confirmed by Southern analysis and PCR. Western analysis failed to detect protein from embryonic liver extracts in homozygous mutant animals. (J:76112)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 41 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hells Mutation:  17 strains or lines available
Original:  J:76112 Geiman TM, et al., Lsh, a SNF2 family member, is required for normal murine development. Biochim Biophys Acta. 2001 May 3;1526(2):211-20
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory