Comt^tm1Kara
Targeted Allele Detail

Summary

• Symbol: Comt^tm1Kara
• Name: catechol-O-methyltransferase; targeted mutation 1, Maria Karayiorgou
• MGI ID: MGI:2178542
• Synonyms: COMT^-, COMT-ko
• Gene: Comt Location: Chr16:18225636-18245602 bp, - strand Genetic Position: Chr16, 11.4 cM
• Alliance: Comt^tm1Kara page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49475
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exons 2-4. Northern blot analysis on RNA derived from brain and liver of homozygous mice demonstrated that no detectable transcript was produced from this allele. Activity assays confirmed that no functional protein was expressed in homozygotes. (J:49475)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Comt Mutation: 23 strains or lines available

References

• Original: J:49475 Gogos JA, et al., Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9991-6
• All: 41 reference(s)