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Dll3tm1Rbe
Targeted Allele Detail
Summary
Symbol: Dll3tm1Rbe
Name: delta like canonical Notch ligand 3; targeted mutation 1, Rosa Beddington
MGI ID: MGI:2178443
Synonyms: Dll3neo
Gene: Dll3  Location: Chr7:27992980-28001210 bp, - strand  Genetic Position: Chr7, 16.67 cM
Alliance: Dll3tm1Rbe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75954
Parent Cell Line:  CGR8 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details5.4 kb of genomic sequence, including amino acids G135-S556 containing the DSL (Notch binding domain), all EGF repreats and the transmembrane domain was replaced with a PGK-neo cassette. (J:75954)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 85 assay results
3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 13 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dll3 Mutation:  40 strains or lines available
References
Original:  J:75954 Dunwoodie SL, et al., Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. Development. 2002 Apr;129(7):1795-806
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory