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Bomd4C57BL/6
QTL Variant Detail
Summary
QTL variant: Bomd4C57BL/6
Name: bone mineral density 4; C57BL/6
MGI ID: MGI:2178275
QTL: Bomd4  Location: unknown  Genetic Position: Chr7, cM position of peak correlated region/allele: 15.42 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers decreased bone mineral density compared to DBA/2.
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:75820

18 BXD (B=C57BL/6, D=DBA/2) recombinant inbred (RI) strains were used to map QTLs associated with bone mineral density. Two sex-specific loci were identified on mouse Chromosome 2 and mouse Chromosome 7, and confirmed in a (C57BL/6 x DBA/2)F2 population. Bomd3 is a female specific locus mapping to Chromosome 2 near D2Mit94 at approximately 48 cM. DBA/2-derived alleles appear to confer increased bone mass in a dominant fashion at Bomd3. Bomd4 is a male specific locus and maps to Chromosome 7 near D7Mit114 at approximately 8 cM. DBA/2-derived alleles appear to confer increased bone mineral density in an additive or dominant fashion at Bomd4.

References
Original:  J:75820 Orwoll ES, et al., Gender specificity in the genetic determinants of peak bone mass. J Bone Miner Res. 2001 Nov;16(11):1962-71
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory