Foxa3^tm1Khk
Targeted Allele Detail

Summary

• Symbol: Foxa3^tm1Khk
• Name: forkhead box A3; targeted mutation 1, Klaus H Kaestner
• MGI ID: MGI:2178218
• Synonyms: Hnf3g-
• Gene: Foxa3 Location: Chr7:18747209-18757463 bp, - strand Genetic Position: Chr7, 9.46 cM
• Alliance: Foxa3^tm1Khk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17631
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette containing lacZ and neo was replaced most of the coding region and 5.5 kb of 3' flanking sequence. While expression of lacZ was observed in nasal and colonic epithelia, it was unobserved in the liver, pancreas, stomach, and small intestines. This lack of expression was attributed to the deletion of cis regulatory elements located in the 3' flanking region of the endogenous gene. (J:17631, J:48310)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxa3 Mutation: 18 strains or lines available

References

• Original: J:17631 Kaestner KH, et al., The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution. Genomics. 1994 Apr;20(3):377-85
• All: 13 reference(s)