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Tcf3tm1Cmu
Targeted Allele Detail
Nomenclature
Symbol: Tcf3tm1Cmu
Name: transcription factor 3; targeted mutation 1, Cornelis Murre
MGI ID: MGI:2178119
Synonyms: E2A-
Gene: Tcf3  Location: Chr10:80409514-80433647 bp, - strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67011
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin resistance cassette into the E12-specific exon disrupted the gene. RT-PCR studies of fetal liver and of lung from 5 week old mice detected trace amounts of E47-specific transcript in homozygous mutant mice. The authors predict that both gene products, E12 and E47, are inactivated in this allele. (J:67011)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 48 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf3 Mutation:  20 strains or lines available
Notes
ES cell line = either E14 or E14-derived.

References
Original:  J:67011 Bain G, et al., E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell. 1994 Dec 2;79(5):885-92
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory