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Krt18tm1Tmm
Targeted Allele Detail
Nomenclature
Symbol: Krt18tm1Tmm
Name: keratin 18; targeted mutation 1, Thomas M Magin
MGI ID: MGI:2178045
Synonyms: K18-, K18 null
Gene: Krt18  Location: Chr15:102028216-102032026 bp, + strand  Genetic Position: Chr15, 57.22 cM, cytoband F3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46610
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    An HPRT minigene replaced most of exon 1, intron 1 and exon 2. (J:46610)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Krt18 Mutation:  3 strains or lines available
References
Original:  J:46610 Magin TM, et al., Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates. J Cell Biol. 1998 Mar 23;140(6):1441-51
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory