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Targeted Allele Detail
Symbol: Krt8tm1Rgo
Name: keratin 8; targeted mutation 1, Robert G Oshima
MGI ID: MGI:2178042
Synonyms: K8-, mK8 -
Gene: Krt8  Location: Chr15:101905146-101912777 bp, - strand  Genetic Position: Chr15, 57.2 cM
Germline Transmission:  Earliest citation of germline transmission: J:12899
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a DNA segment containing most of the first exon including the translation initiation codon. Northern blot analysis on RNA isolated from gut, liver, kidney and spleen demonstrated that an aberrant transcript was made in gut, but no transcript was detectable elsewhere. Immunohistochemistry on sections of intestine of homozygous mice confirmed that no detectable protein was expressed from this allele. (J:12899)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Krt8 Mutation:  22 strains or lines available
Original:  J:12899 Baribault H, et al., Mid-gestational lethality in mice lacking keratin 8. Genes Dev. 1993 Jul;7(7A):1191-202
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory