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Srd5a2tm1Mahe
Targeted Allele Detail
Summary
Symbol: Srd5a2tm1Mahe
Name: steroid 5 alpha-reductase 2; targeted mutation 1, Mala Mahendroo
MGI ID: MGI:2178039
Synonyms: 2KO
Gene: Srd5a2  Location: Chr17:74323950-74354911 bp, - strand  Genetic Position: Chr17, 45.39 cM, cytoband E2
Alliance: Srd5a2tm1Mahe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72807
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic segment encompassing a portion of intron 1 through a portion of exon 3. Activity assays demonstrated the loss of protein function in homozygous mice. (J:72807)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Srd5a2 Mutation:  17 strains or lines available
Notes
ES cell line = I1C.
References
Original:  J:72807 Mahendroo MS, et al., Unexpected virilization in male mice lacking steroid 5alpha-reductase enzymes. Endocrinology. 2001 Nov;142(11):4652-62
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory