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Targeted Allele Detail
Symbol: Smarcad1tm1Gos
Name: SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1; targeted mutation 1, Achim Gossler
MGI ID: MGI:2177964
Synonyms: Etl1leo, Etl1TgN(6LSN)3Gos
Gene: Smarcad1  Location: Chr6:65042591-65116061 bp, + strand  Genetic Position: Chr6, 30.11 cM
Germline Transmission:  Earliest citation of germline transmission: J:56661
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA lacZ-neomycin fusion gene was inserted in-frame immediately downstream of the initiation codon. Western blot analysis on doubly targeted ES cells confirmed that no ETL1 protein was expressed from this allele; however, beta-galactosidase was expressed under the control of the endogenous promoter. (J:56661)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 92 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smarcad1 Mutation:  152 strains or lines available
Original:  J:56661 Schoor M, et al., Skeletal dysplasias, growth retardation, reduced postnatal survival, and impaired fertility in mice lacking the SNF2/SWI2 family member ETL1. Mech Dev. 1999 Jul;85(1-2):73-83
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory