Smarcad1^tm1Gos
Targeted Allele Detail

Summary

• Symbol: Smarcad1^tm1Gos
• Name: SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1; targeted mutation 1, Achim Gossler
• MGI ID: MGI:2177964
• Synonyms: Etl1^leo, Etl1^{TgN(6LSN)3Gos}
• Gene: Smarcad1 Location: Chr6:65019577-65093045 bp, + strand Genetic Position: Chr6, 30.11 cM
• Alliance: Smarcad1^tm1Gos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56661
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ-neomycin fusion gene was inserted in-frame immediately downstream of the initiation codon. Western blot analysis on doubly targeted ES cells confirmed that no ETL1 protein was expressed from this allele; however, beta-galactosidase was expressed under the control of the endogenous promoter. (J:56661)

Disease models

Expression

In Mice Carrying this Mutation:	92 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smarcad1 Mutation: 191 strains or lines available

References

• Original: J:56661 Schoor M, et al., Skeletal dysplasias, growth retardation, reduced postnatal survival, and impaired fertility in mice lacking the SNF2/SWI2 family member ETL1. Mech Dev. 1999 Jul;85(1-2):73-83
• All: 1 reference(s)