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Targeted Allele Detail
Symbol: Etv6tm1Sho
Name: ets variant 6; targeted mutation 1, Stuart H Orkin
MGI ID: MGI:2177950
Synonyms: TEL -
Gene: Etv6  Location: Chr6:134035700-134270158 bp, + strand  Genetic Position: Chr6, 64.58 cM, cytoband G2
Germline Transmission:  Earliest citation of germline transmission: J:42409
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a DNA segment that contains exons coding for the DNA-binding domain. Northern blot and RT-PCR analysis on RNA derived from double-targeted ES cells demonstrated that no detectable transcript was produced from this allele. (J:42409)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Etv6 Mutation:  124 strains or lines available
Original:  J:42409 Wang LC, et al., Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL. EMBO J. 1997 Jul 16;16(14):4374-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
The Jackson Laboratory