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Targeted Allele Detail
Symbol: Pin1tm1Tuc
Name: protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1; targeted mutation 1, Takafumi Uchida
MGI ID: MGI:2177943
Synonyms: Pin1-
Gene: Pin1  Location: Chr9:20652118-20663712 bp, + strand  Genetic Position: Chr9, 7.6 cM
Reduced body weight and testicular atrophy in Pin1tm1Tuc/Pin1tm1Tuc mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:58734
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced exons 1-4, which contain the entire coding sequence of the gene. Western blot analysis on embryonic fibroblasts derived from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:58734)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pin1 Mutation:  17 strains or lines available
Original:  J:58734 Fujimori F, et al., Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest. Biochem Biophys Res Commun. 1999 Nov 30;265(3):658-63
All:  57 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory