Capn3tm1Jsb
Targeted Allele Detail
|
Symbol: |
Capn3tm1Jsb |
Name: |
calpain 3; targeted mutation 1, Jacques S Beckmann |
MGI ID: |
MGI:2177929 |
Synonyms: |
CAPN3-, Capn3tm2.1Gnt |
Gene: |
Capn3 Location: Chr2:120294074-120335400 bp, + strand Genetic Position: Chr2, 60.31 cM
|
Alliance: |
Capn3tm1Jsb page
|
|
Dystrophic muscle in Capn3tm1Jsb/Capn3tm1Jsb mice
Show the 1 phenotype image(s) involving this allele.
|
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:66862
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
129/Sv
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: A genomic fragment containing exons 2 and 3 was replaced by a neomycin selection cassette. Western blot analysis on muscle extracts derived from homozygous mice confirmed that no detectable protein was expressed from this allele.
(J:66862)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Capn3 Mutation: |
48 strains or lines available
|
|
Original: |
J:66862 Richard I, et al., Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/nuclear factor kappaB pathway perturbation in mice. J Cell Biol. 2000 Dec 25;151(7):1583-90 |
All: |
9 reference(s) |
|