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Targeted Allele Detail
Symbol: Capn3tm1Jsb
Name: calpain 3; targeted mutation 1, Jacques S Beckmann
MGI ID: MGI:2177929
Synonyms: CAPN3-, Capn3tm2.1Gnt
Gene: Capn3  Location: Chr2:120463593-120504919 bp, + strand  Genetic Position: Chr2, 60.31 cM
Dystrophic muscle in Capn3tm1Jsb/Capn3tm1Jsb mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:66862
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exons 2 and 3 was replaced by a neomycin selection cassette. Western blot analysis on muscle extracts derived from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:66862)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Capn3 Mutation:  9 strains or lines available
Original:  J:66862 Richard I, et al., Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/nuclear factor kappaB pathway perturbation in mice. J Cell Biol. 2000 Dec 25;151(7):1583-90
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory