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Targeted Allele Detail
Symbol: Mapk14tm1Nbr
Name: mitogen-activated protein kinase 14; targeted mutation 1, Angel R Nebreda
MGI ID: MGI:2177831
Synonyms: p38alpha -
Gene: Mapk14  Location: Chr17:28691342-28748405 bp, + strand  Genetic Position: Chr17, 14.85 cM
Germline Transmission:  Earliest citation of germline transmission: J:63877
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn internal 2 kb genomic fragment was replaced with a lacZ gene and a PGK-neomycin cassette. The deleted region contains two exons encoding amino acids 40-103, which includes most of the amino-terminal lobe of the catalytic domain including the glycine-rich ATP binding loop. Western blot analysis of lysates prepared from E10.5 embryos confirmed that no detectable protein was expressed from this allele. (J:63877)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapk14 Mutation:  29 strains or lines available
Original:  J:63877 Adams RH, et al., Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell. 2000 Jul;6(1):109-16
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory