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Targeted Allele Detail
Symbol: Kmt2atm1Vss
Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1, Vasanta Subramanian
MGI ID: MGI:2177819
Gene: Kmt2a  Location: Chr9:44803355-44881296 bp, - strand  Genetic Position: Chr9, 24.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:71498
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsAn IRES-lacZ gene followed by a neomycin selection cassette was inserted into exon 5. RT-PCR analysis confirmed the expression of a mutant transcipt, and whole mount staining of embryos demonstrated that beta-galactosidase was expressed from this allele. (J:71498)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kmt2a Mutation:  79 strains or lines available
Original:  J:71498 Ayton P, et al., Truncation of the MLL gene in exon 5 by gene targeting leads to early preimplantation lethality of homozygous embryos. Genesis. 2001 Aug;30(4):201-12
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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