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Kmt2atm1Tok
Targeted Allele Detail
Nomenclature
Symbol: Kmt2atm1Tok
Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1, Toshihisa Komori
MGI ID: MGI:2177818
Synonyms: MLL-, Mllmu
Gene: Kmt2a  Location: Chr9:44803355-44881296 bp, - strand  Genetic Position: Chr9, 24.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48502
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic segment containing exons 12-14. Aberrant transcripts were produced from this allele that are predicted to produce a nonfunctional protein, if any. (J:48502)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kmt2a Mutation:  55 strains or lines available
References
Original:  J:48502 Yagi H, et al., Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice. Blood. 1998 Jul 1;92(1):108-17
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory